‘Cures’ for HIV in 2 more people 1 male as a result of cancer therapy, and 1 lady who eerily acquired natural viral control

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During AIDS 2022, two additional individuals were declared to have “functionally cured” of HIV. One male patient received bone marrow from a donor who is immune to HIV. The other person, a woman, is a “elite controller” of the infection due to her “atypical” quantity of special cells that may attack HIV. The human immunodeficiency virus has “been cured” in two more HIV-positive patients, researchers said this week at AIDS 2022 in Montreal.

The second person, a lady who appears to have a peculiar and unique natural ability to manage the virus after therapy, is a cancer sufferer.

The discoveries, which were made by two very different ways and are both still extremely rare, offer two unique rays of hope for HIV/AIDS researchers looking for a treatment for the disease. Since there is no way to be positive if the cures are long-lasting, scientists prefer to refer to these patients as being in “long term remission.” But in both of the new cases, there has been little to no sign of HIV replication in their bodies for a number of years, which is a good indication that this isn’t a short-term solution.

Similar cases to these two individuals have been reported in numerous other locations recently, and the spread of these two different “cures” is accelerating.
The first “CURE” is a unique form of cancer treatment.

cancer center in California where he was treated for leukemia).

The patient at City of Hope reportedly experienced a “cure” as a result of a bone marrow transplant that included HIV-resistant cells. The patient, who is now 66 years old, got a transplant for leukemia at the age of 63 after having lived with HIV for 31 years.

During a presentation on Monday at the AIDS 2022 conference in Montreal, his doctor, Jana Dickter, stated that he has “no evidence of HIV replication” in his body.

She explained that the goal of the transplant was to treat the patient’s lukemia, but the same approach might be effective for others who are later given the diagnosis of having both HIV and lukemia.

Similar bone marrow transplants have effectively “cured” HIV in at least two other individuals, including the Berlin Patient (in 2007) and the London Patient (announced in 2019). Using a cutting-edge umbilical cord blood transplant, also for blood cancer, a woman in New York became the first female lukemia patient to be deemed “possibly” HIV-cured in February.

In all of these well-known examples, cancer patients received HIV-resistant blood cell transplants from donors who had particular virus-busting mutations. There is a second man from Dusseldorf, Germany who appears to have been cured in a similar way , but his doctors have been less open about discussing his case in academic journals.

Dickter noted that although the City of Hope patient’s medication won’t be a universal panacea for all HIV-positive people worldwide, “we’re seeing more blood malignancies” in elderly HIV-positive patients in the US at the moment, and this approach may benefit some of them.

“CURE” #2: “ELITE” NATURAL CONTROL OF THE DISEASE

other HIV “cure” announced at AIDS 2022 was a Spanish woman who stopped using popular HIV antiviral medications and has virtually remained HIV-free for 15 years. (Usually, individuals rebound after stopping their HIV medications.)

She is thought to be a member of an uncommon global population known as “elite controllers,” whose bodies automatically combat and suppress HIV, sometimes even curing it completely without the use of medications.

The overall amount of HIV-1 DNA in the anonymous patient was decreased by 98%, according to Dr. Nuria Climent Vidal of Barcelona.

At the briefing on Sunday, Vidal remarked, “Maybe she has special hereditary elements.” He also noted that the patient has a “atypical” amount of unique natural killer cells that may fight HIV.

There are believed to be at least two more occurrences of natural HIV control in recent years, while it is unknown how many of these elite controllers there are in the world.

Another so-called “elite controller,” Californian Loreen Willenberg, who caught HIV in 1992, shows no evidence of the virus in her body. A second woman who received an HIV diagnosis in 2013 in Argentina also experienced natural control. Her 2020-born daughter is HIV-free, which is typically only possible with antiretroviral therapy (ART) HIV drug treatments during pregnancy.

For the tens of millions of people living with HIV worldwide who do not have blood cancer, the “elite controller” findings—achieved with or without drugs—are arguably more intriguing. While somewhat unclear, the process behind elite control is “possibly translatable to other people,” according to Dr. Bruce Walker , an HIV researcher at the Ragon Institute in Massachusetts.

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