In the middle of an IVF operation, a 23-year-old lady passed away on the operating table. Her sensitivity to the hormones that promote egg growth was unusual.


Ovarian hyperstimulation syndrome, a severe form of it, caused a lady to pass away during an IVF surgery. IVF medications that overstimulate the ovaries can cause OHSS by producing substances that cause blood vessels to bleed. The unidentified woman was ‘healthy’ before to the treatment, the paper said. There are over 3 million readers of Morning Brew.

You ought to, too! Thank you for registering! A regular in vitro fertilization (IVF) operation ended in the death of a 23-year-old woman on the operating table when a rare complication led to fluid accumulation in her lungs and her inability to breathe.

Ovarian medications used in IVF overstimulate the ovaries, causing chemical release that leads to ovarian hyperstimulation syndrome (OHSS). In severe situations, those substances lead to fluid leakage from blood vessels into the abdomen, the area around the heart, and the lungs. The generally usually appears a week after the medications are taken, but it sometimes takes longer.

According to the Royal College of Obstetricians and Gynecologists, mild OHSS, which produces symptoms including abdominal swelling, pain, and nausea, is relatively frequent, affecting 33% of women undergoing IVF. According to RCOG, symptoms typically improve on their own within seven to ten days without treatment.

However, according to RCOG. , just little more than 1% of women having IVF may experience moderate or severe OHSS. Symptoms include intense thirst, symptoms of dehydration like dark urine, and breathing difficulties if there is fluid in the lungs. A rare complication of severe OHSS is blood clots in the legs or lungs, which can result in swollen, painful legs or chest pain and shortness of breath.

In the instance of the anonymous woman who passed away, a physical examination and the results of blood tests before an IVF operation to collect her eggs showed she was a “healthy, young woman,” according to medical professionals from New Delhi, India, wrote in a report in a journal called Autopsy and Case Reports. They claimed that she had a healthy 4-year-old daughter who was born naturally.

According to RCOG, those with PCOS, those under 30, those who have experienced OHSS before, and those who become pregnant during the same cycle as experiencing OHSS symptoms, such as abdominal pain and vomiting, are at increased risk of severe OHSS, which necessitates hospital treatment and specialized care.

Although the cause of the problem is unknown, the authors of the case report speculate that the patient’s young age and high blood levels of a particular form of estrogen may have had a role.

They explained how after doctors removed an egg from the woman’s right ovary, her blood pressure plummeted, her heart rate slowed, and her oxygen levels dropped, forcing them to stop the treatment. THE WOMAN HAD A CARDIAC ARREST AS A RESULT OF OHSS.

They attempted to revive the woman when they couldn’t discover a heartbeat. She stopped breathing and experienced a heart arrest, dying on the operating table as a result.

The case report authors stated that individuals having egg removal for IVF “should be thoroughly educated about the hazards associated with egg donation.”

OHSS-RELATED DEATH IS “VANISHINGLY RARE” Sarah Norcross, director of the reproductive charity Progress Educational Trust (PET), tells aa6 that OHSS-related death is “vanishingly rare.”

Research suggests that OHSS, among other problems, can occur either during or after egg removal. Infections, blood in the urine, and ovarian torsion—when an ovary twists around its ligaments and cuts off its own blood supply—are examples of further difficulties.